Aluminium a metal used every day in items such as consumer goods, transport, construction and electrical appliances has been linked with the 2nd most common cause of death in the world ‘Alzheimer’s Disease’ so claims the second study completed in humans.
A recent research study conducted by (Mold et al., 2020) confirmed for the second time that significantly high brain aluminium is linked with Alzheimer’s disease (AD). Using data from a Columbian cohort of individuals the researchers found 42% of brain tissues had aluminium concentration above the pathologically accepted levels.
The brain tissues were monitored in individuals with familial AD and with a specific mutation of the gene PS1-E280A, which results in elevated cortical levels of amyloid-beta (the main component of the amyloid plaques found in the brains of people with Alzheimer’s disease), early onset of the disease and aggressive disease. The brain tissue was compared in the study with controls, of which did not have the neuropathological disease.
The findings showed around two thirds of aluminium deposits were identified in grey matter and were location in addition to the amyloid-beta deposits. There was shown to be no significant relationship with age and this metals content, although gender differences presented females having higher aluminium content than males.
The researchers discuss an intricate link between neurological familiar AD and deposits of aluminium and amyloid-beta with lead investigator Dr Exley conveying an unequivocal association between aluminium and amyloid-beta especially in individuals with a genetic predisposition. One could say no aluminium = no AD.
MOLD, M., LINHART, C., GOMEZ-RAMIREZ, J., VILLEGAS-LANAU, A. & EXLEY, C. 2020. Aluminum and Amyloid-beta in Familial Alzheimer’s Disease. J Alzheimers Dis. [Online] Accessed 28 January 2020 Available at https://content.iospress.com/articles/journal-of-alzheimers-disease/jad191140